Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Matthew Berg
LAB HEAD: Judit Villen
PROVIDER: PXD032063 | Pride | 2022-08-12
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 11 |
Berg Matthew D MD Zhu Yanrui Y Loll-Krippleber Raphaël R San Luis Bryan-Joseph BJ Genereaux Julie J Boone Charles C Villén Judit J Brown Grant W GW Brandl Christopher J CJ
G3 (Bethesda, Md.) 20220701 7
Transfer RNA variants increase the frequency of mistranslation, the misincorporation of an amino acid not specified by the "standard" genetic code, to frequencies approaching 10% in yeast and bacteria. Cells cope with these variants by having multiple copies of each tRNA isodecoder and through pathways that deal with proteotoxic stress. In this study, we define the genetic interactions of the gene encoding tRNASerUGG,G26A, which mistranslates serine at proline codons. Using a collection of yeast ...[more]