Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Xenopus Laevis (african Clawed Frog)
TISSUE(S): Blood
SUBMITTER: Jeffrey Hayes
LAB HEAD: Jeffrey J. Hayes, Ph.D.
PROVIDER: PXD032292 | Pride | 2022-08-12
REPOSITORIES: Pride
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Molecular & cellular proteomics : MCP 20220523 7
As a key structural component of the chromatin of higher eukaryotes, linker histones (H1s) are involved in stabilizing the folding of extended nucleosome arrays into higher-order chromatin structures and function as a gene-specific regulator of transcription in vivo. The H1 C-terminal domain (CTD) is essential for high-affinity binding of linker histones to chromatin and stabilization of higher-order chromatin structure. Importantly, the H1 CTD is an intrinsically disordered domain that undergoe ...[more]