Dataset Information

Analysis of the role of the proteome on lipid nanoparticle distribution

ABSTRACT: Analysis of the role of the proteome on lipid nanoparticle distribution

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver, Blood Serum

SUBMITTER: Justina Clarinda Wolters

LAB HEAD: Justina Clarinda Wolters and Matthias Bartneck

PROVIDER: PXD032311 | Pride | 2023-03-16

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	20211007_2021-33_Matthias_liver1.raw	Raw
	20211007_2021-33_Matthias_liver2.raw	Raw
	20211007_2021-33_Matthias_liver3.raw	Raw
	20211007_2021-33_Matthias_liver4.raw	Raw
	20211007_2021-33_Matthias_liver5.raw	Raw

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Publications

Targeting Ligand Independent Tropism of siRNA-LNP by Small Molecules for Directed Therapy of Liver or Myeloid Immune Cells.

Lin Cheng C Jans Alexander A Wolters Justina Clarinda JC Mohamed Mohamed Ramadan MR Van der Vorst Emiel P C EPC Trautwein Christian C Bartneck Matthias M

Advanced healthcare materials 20230108 26

Hepatic clearance of lipid nanoparticles (LNP) with encapsulated nucleic acids restricts their therapeutic applicability. Therefore, tools for regulating hepatic clearance are of high interest for nucleic acid delivery. To this end, this work employs wild-type (WT) and low-density lipoprotein receptor (Ldlr)<sup>-/-</sup> mice pretreated with either a leukotriene B4 receptor inhibitor (BLT1i) or a high-density lipoprotein receptor inhibitor (HDLRi) prior to the injection of siRNA-LNP. This work ...[more]

PMID: 36617516

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