Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Eclipse
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Primary Neuron
DISEASE(S): Parkinson's Disease
SUBMITTER: Jonathan Van Vranken
LAB HEAD: Bruce Spiegelman
PROVIDER: PXD032670 | Pride | 2022-10-15
REPOSITORIES: Pride
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Kam Tae-In TI Park Hyejin H Chou Shih-Ching SC Van Vranken Jonathan G JG Mittenbühler Melanie J MJ Kim Hyeonwoo H A Mu M Choi Yu Ree YR Biswas Devanik D Wang Justin J Shin Yu Y Loder Alexis A Karuppagounder Senthilkumar S SS Wrann Christiane D CD Dawson Valina L VL Spiegelman Bruce M BM Dawson Ted M TM
Proceedings of the National Academy of Sciences of the United States of America 20220831 36
Physical activity provides clinical benefit in Parkinson's disease (PD). Irisin is an exercise-induced polypeptide secreted by skeletal muscle that crosses the blood-brain barrier and mediates certain effects of exercise. Here, we show that irisin prevents pathologic α-synuclein (α-syn)-induced neurodegeneration in the α-syn preformed fibril (PFF) mouse model of sporadic PD. Intravenous delivery of irisin via viral vectors following the stereotaxic intrastriatal injection of α-syn PFF cause a re ...[more]