Proteomics

Dataset Information

0

Proteomics and Metabolomics unveils Codonopsis Radix ameliorates Gastric Precancerous Lesions via regulating energy metabolism

ABSTRACT: Modern pharmacology has proved that Codonopsis Radix and its active ingredients can treat stomach diseases by ameliorating gastrointestinal motility and regulating oxidase levels. However, the detailed molecular mechanism is still unclear. In this study, we systematically evaluated the pharmacodynamic effects of Codonopsis Radix in Gastric Precancerous Lesions animal models. Considering the combination of proteomics and metabolomics, we found that CR could significantly reversed the biological pathways related to energy metabolism which were disturbed by GPL model. Furthermore, the results of serum pharmacology indicated that the Codonopsis Radix contained serum could ameliorate gastritis injury, and selectively inhibit the proliferation of gastric cancer cells rather than normal cells, which was closely related to ATP production in above cells.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Stomach

DISEASE(S): Stomach Disease

SUBMITTER: 茹芸 马  

LAB HEAD: Jianye Dai

PROVIDER: PXD032714 | Pride | 2022-10-15

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
20201125_DAI_R1_01.raw Raw
20201125_DAI_R2_01.raw Raw
20201125_DAI_R3_01.raw Raw
20201125_DAI_R4_01.raw Raw
20201125_DAI_R5_01.raw Raw
Items per page:
1 - 5 of 7
altmetric image

Publications

Proteomics and Metabolomics Unveil <i>Codonopsis pilosula</i> (Franch.) Nannf. Ameliorates Gastric Precancerous Lesions <i>via</i> Regulating Energy Metabolism.

He Rupu R   Ma Ruyun R   Jin Zheng Z   Zhu Yanning Y   Yang Fude F   Hu Fangdi F   Dai Jianye J  

Frontiers in pharmacology 20220719

<b>Objective:</b> This study aimed to systematically evaluate the efficacy of <i>Codonopsis pilosula</i> (Franch.) Nannf. (<i>Codonopsis Radix</i>, CR) and reveal the mechanism of its effects on suppressing Gastric Precancerous Lesions. <b>Methods:</b> First, we established the GPL rat model which was induced by N-methyl-N'-nitro-N-nitrosoguanidine, a disordered diet, and 40% ethanol. The CR's anti-Gastric Precancerous Lesions effect was comprehensively evaluated by body weight, pathological sec  ...[more]

Similar Datasets

Proteomics Quantitative Proteomics Revealed the Changes of Pharmacodynamic Network of Bugu Shengsui Decoction Promoting Osteoblasts Proliferation
2022-01-28 | PXD030275 | Pride
Proteomics Proteomic comparison of uninfected and wMelPop infected Aag2 cells
2017-09-19 | PXD003429 | Pride
Proteomics Cell-type-specific labeling and profiling of glycans in living mice
2022-02-28 | PXD030663 | Pride
Transcriptomics The analysis of gene transcription and the effect of drug resistance of Radix Paeoniae Rubra Decoction on Staphylococcus aureus
2021-01-30 | GSE165791 | GEO
Proteomics AtLEGbeta / gamma protease specificity characterization by PICS
2020-07-29 | PXD019220 | Pride
Transcriptomics Exploration of the synergistic mechanism of Gegen Qinlian Decoction on Wnt signaling pathway based on an integrated strategy of network pharmacology and transcriptomics
2023-08-12 | GSE157181 | GEO
Proteomics I/L-discrimination by MS3 of dimethylated peptides
2018-07-24 | PXD009295 | Pride
Proteomics Active thrombin is produced by intestinal epithelium to control mucosal biofilm
2019-06-24 | PXD014315 | Pride
Proteomics Nasal septum deviation as the consequence of BMP-controlled changes to cartilage properties
2021-04-30 | PXD024813 | Pride
Proteomics EGR1 regulation in human bone marrow stromal cells
2019-06-27 | PXD011767 | Pride