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A Dual-Acting Nitric Oxide Donor and Phosphodiesterase 5 Inhibitor Activates Autophagy in Primary Skin Fibroblasts

ABSTRACT: In the project “A Dual-Acting Nitric Oxide Donor and Phosphodiesterase 5 Inhibitor Activates Autophagy in Primary Skin Fibroblasts» by Esther Martínez-Martínez and Joern Dengjel, we performed expression proteomics analyzing the response of normal human fibroblasts (NHF) isolated from healthy skin to the drug TOP-N53.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Skin, Fibroblast

SUBMITTER: Joern Dengjel

LAB HEAD: Joern Dengjel

PROVIDER: PXD032893 | Pride | 2022-06-25

REPOSITORIES: Pride

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			Action	DRS
	20201103_EM_HighGlc_TPN53_1.raw	Raw
	20201103_EM_HighGlc_TPN53_2.raw	Raw
	20201103_EM_HighGlc_TPN53_3.raw	Raw
	20201103_EM_HighGlc_Veh_1.raw	Raw
	20201103_EM_HighGlc_Veh_2.raw	Raw

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Publications

A Dual-Acting Nitric Oxide Donor and Phosphodiesterase 5 Inhibitor Activates Autophagy in Primary Skin Fibroblasts.

Martínez-Martínez Esther E Atzei Paola P Vionnet Christine C Roubaty Carole C Kaeser-Pebernard Stephanie S Naef Reto R Dengjel Jörn J

International journal of molecular sciences 20220620 12

Wound healing pathologies are an increasing problem in ageing societies. Chronic, non-healing wounds, which cause high morbidity and severely reduce the quality of life of affected individuals, are frequently observed in aged individuals and people suffering from diseases affected by the Western lifestyle, such as diabetes. Causal treatments that support proper wound healing are still scarce. Here, we performed expression proteomics to study the effects of the small molecule TOP-N53 on primary h ...[more]

PMID: 35743299

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