Ontology highlight
ABSTRACT:
INSTRUMENT(S): impact HD
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: John Burke
LAB HEAD: Dr. John E. Burke
PROVIDER: PXD032929 | Pride | 2023-02-22
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 225 |
Shaw Alexandria L AL Parson Matthew A H MAH Truebestein Linda L Jenkins Meredith L ML Leonard Thomas A TA Burke John E JE
Structure (London, England : 1993) 20230208 3
Akt is a master regulator of pro-growth signaling in the cell. Akt is activated by phosphoinositides that disrupt the autoinhibitory interface between the kinase and pleckstrin homology (PH) domains and then is phosphorylated at T308 and S473. Akt hyperactivation is oncogenic, which has spurred development of potent and selective inhibitors as therapeutics. Using hydrogen deuterium exchange mass spectrometry (HDX-MS), we interrogated the conformational changes upon binding Akt ATP-competitive an ...[more]