Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Trypanosoma Brucei
TISSUE(S): Cell Culture
SUBMITTER: Julian Bender
LAB HEAD: Bettina Warscheid
PROVIDER: PXD033042 | Pride | 2022-06-02
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
20220330_mtHSP60-p166-HA.fasta | Fasta | |||
20220330_mtHSP60-p166-HA_short.fasta | Fasta | |||
QEplus033937.raw | Raw | |||
QEplus033939.raw | Raw | |||
QEplus033942.raw | Raw |
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PLoS pathogens 20220616 6
The protist parasite Trypanosoma brucei has a single mitochondrion with a single unit genome termed kinetoplast DNA (kDNA). Faithfull segregation of replicated kDNA is ensured by a complicated structure termed tripartite attachment complex (TAC). The TAC physically links the basal body of the flagellum with the kDNA spanning the two mitochondrial membranes. Here, we characterized p166 as the only known TAC subunit that is anchored in the inner membrane. Its C-terminal transmembrane domain separa ...[more]