Proteomics

Dataset Information

0

LC-MS/MS of human MFN2 interaction proteins


ABSTRACT: LC-MS/MS of human MFN2 interaction proteins from 293T cells or 786-O cells

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Kidney Cell

DISEASE(S): Kidney Cancer

SUBMITTER: Gao Song  

LAB HEAD: Gao Song

PROVIDER: PXD033112 | Pride | 2023-10-24

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20201112-YJF-786-0.mgf Mgf
20201112YJF-293T.mgf Mgf
293T.raw Raw
2_peptides_1_1_0.mzid.gz Mzid
786-0.raw Raw
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Publications

MFN2 suppresses clear cell renal cell carcinoma progression by modulating mitochondria-dependent dephosphorylation of EGFR.

Luo Li L   Wei Denghui D   Pan Yihui Y   Wang Qiu-Xia QX   Feng Jian-Xiong JX   Yu Bing B   Kang Tiebang T   Luo Junhang J   Yang Jiefeng J   Gao Song S  

Cancer communications (London, England) 20230628 7


<h4>Background</h4>Clear cell renal cell carcinoma (ccRCC) is the most lethal renal cancer. An overwhelming increase of patients experience tumor progression and unfavorable prognosis. However, the molecular events underlying ccRCC tumorigenesis and metastasis remain unclear. Therefore, uncovering the underlying mechanisms will pave the way for developing novel therapeutic targets for ccRCC. In this study, we sought to investigate the role of mitofusin-2 (MFN2) in supressing ccRCC tumorigenesis  ...[more]

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