Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Monocyte, Blood
DISEASE(S): Adult Respiratory Distress Syndrome
SUBMITTER: Ananda Mirchandani
LAB HEAD: Sarah Walmsley
PROVIDER: PXD033151 | Pride | 2022-08-12
REPOSITORIES: Pride
Items per page: 1 - 5 of 37 |
Nature immunology 20220527 6
Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, yet the resulting tissue hypoxia, and its impact on immune responses, is often neglected. In the present study, we have shown that ARDS patients were hypoxemic and monocytopenic within the first 48 h of ventilation. Monocytopenia was also observed in mouse models of hypoxic acute lung injury, in which hypoxemia drove the suppression of type I interfero ...[more]