Dataset Information
Analysis of the proteome of epithelial cells from mice with specific deletion of DHPS
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Colon Epithelial Cell, Colon
DISEASE(S): Colon Cancer,Colitis
SUBMITTER: 
Kristie Lindsey Rose
LAB HEAD: Kristie Lindsey Rose
PROVIDER: PXD033228 | Pride | 2024-10-17
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 5774_PD_Peptides.xlsx | Xlsx | |||
| 5774_PD_Proteins.xlsx | Xlsx | |||
| checksum.txt | Txt | |||
| pQE1_klr_5774_20210305_TMTBRP10percent_3uL_1.raw | Raw | |||
| pQE1_klr_5774_20210305_TMTBRP12percent_3uL_2.raw | Raw |
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Publications
Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification.
Gastroenterology 20230602 3
<h4>Background & aims</h4>The amino acid hypusine, synthesized from the polyamine spermidine by the enzyme deoxyhypusine synthase (DHPS), is essential for the activity of eukaryotic translation initiation factor 5A (EIF5A). The role of hypusinated EIF5A (EIF5A<sup>Hyp</sup>) remains unknown in intestinal homeostasis. Our aim was to investigate EIF5A<sup>Hyp</sup> in the gut epithelium in inflammation and carcinogenesis.<h4>Methods</h4>We used human colon tissue messenger RNA samples and publicly ...[more]
