Dataset Information

Murine IgG (polyclonal) from Listeria Challenged pregnant dams

ABSTRACT: IgG was collected from virgin and pregnant listeria challenged mouse plasma. Polyclonal IgG was analyzed by reduction, alkylation, and LC-MS with top-down MS/MS (HCD and ETD)to look for glycosylation PTMs

INSTRUMENT(S): Orbitrap Eclipse

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Plasma

SUBMITTER: Stephanie Archer-Hartmann

LAB HEAD: Dr. Parastoo Azadi

PROVIDER: PXD033357 | Pride | 2022-06-28

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	coverage_pLM_IgG.raw.zip	Raw
	coverage_pLM_sialicacid_EThcD.raw.zip	Raw
	coverage_pLm_1802.raw.zip	Raw
	coverage_vLM_IgG.raw.zip	Raw
	coverage_vLM_sialicacid_EThcD.raw.zip	Raw

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Publications

Pregnancy enables antibody protection against intracellular infection.

Erickson John J JJ Archer-Hartmann Stephanie S Yarawsky Alexander E AE Miller Jeanette L C JLC Seveau Stephanie S Shao Tzu-Yu TY Severance Ashley L AL Miller-Handley Hilary H Wu Yuehong Y Pham Giang G Wasik Brian R BR Parrish Colin R CR Hu Yueh-Chiang YC Lau Joseph T Y JTY Azadi Parastoo P Herr Andrew B AB Way Sing Sing SS

Nature 20220608 7915

Adaptive immune components are thought to exert non-overlapping roles in antimicrobial host defence, with antibodies targeting pathogens in the extracellular environment and T cells eliminating infection inside cells<sup>1,2</sup>. Reliance on antibodies for vertically transferred immunity from mothers to babies may explain neonatal susceptibility to intracellular infections<sup>3,4</sup>. Here we show that pregnancy-induced post-translational antibody modification enables protection against the ...[more]

PMID: 35676476

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