Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Eclipse
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Blood Plasma
SUBMITTER: Stephanie Archer-Hartmann
LAB HEAD: Dr. Parastoo Azadi
PROVIDER: PXD033357 | Pride | 2022-06-28
REPOSITORIES: pride
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coverage_pLM_IgG.raw.zip | Raw | |||
coverage_pLM_sialicacid_EThcD.raw.zip | Raw | |||
coverage_pLm_1802.raw.zip | Raw | |||
coverage_vLM_IgG.raw.zip | Raw | |||
coverage_vLM_sialicacid_EThcD.raw.zip | Raw |
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Erickson John J JJ Archer-Hartmann Stephanie S Yarawsky Alexander E AE Miller Jeanette L C JLC Seveau Stephanie S Shao Tzu-Yu TY Severance Ashley L AL Miller-Handley Hilary H Wu Yuehong Y Pham Giang G Wasik Brian R BR Parrish Colin R CR Hu Yueh-Chiang YC Lau Joseph T Y JTY Azadi Parastoo P Herr Andrew B AB Way Sing Sing SS
Nature 20220608 7915
Adaptive immune components are thought to exert non-overlapping roles in antimicrobial host defence, with antibodies targeting pathogens in the extracellular environment and T cells eliminating infection inside cells<sup>1,2</sup>. Reliance on antibodies for vertically transferred immunity from mothers to babies may explain neonatal susceptibility to intracellular infections<sup>3,4</sup>. Here we show that pregnancy-induced post-translational antibody modification enables protection against the ...[more]