Dataset Information

Role of circNFKB1 in cartilage degeneration of knee osteoarthritis and its mechanism

ABSTRACT: Circular RNAs (circRNAs) are covalently closed single-stranded RNA molecules produced by reverse splicing of the precursor mRNAs of thousands of gene exons in eukaryotes. Some circRNAs play potentially important roles at the molecular level through different modes of action in physiological and pathological conditions. In recent years, it has been found that differentially expressed circRNAs are present in chondrocyte degeneration in OA and are able to modulate the inflammatory response in chondrocyte degeneration. However, the molecular mechanisms of how circRNAs regulate the inflammatory response during chondrogenic degeneration in OA have not been adequately studied. Are there other circRNAs involved in regulating the inflammatory response during knee OA chondrocyte degeneration and are there other molecular mechanisms by which circRNAs regulate chondrocyte degeneration? These scientific questions deserve relevant studies.

INSTRUMENT(S): Dionex instrument model, Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Chondrocyte

DISEASE(S): Osteoarthritis

SUBMITTER: Nie Xiaoyu

LAB HEAD: Changhai Ding

PROVIDER: PXD033469 | Pride | 2022-10-15

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	NXY.mgf	Mgf
	NXY.raw	Raw

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Publications

Circular RNA circNFKB1 promotes osteoarthritis progression through interacting with ENO1 and sustaining NF-κB signaling.

Tang Su'an S Nie Xiaoyu X Ruan Jianzhao J Cao Yumei Y Kang Jingliang J Ding Changhai C

Cell death & disease 20220809 8

Inflammatory cytokines-induced activation of the nuclear factor κB (NF-κB) pathway plays a critical role in the pathogenesis of osteoarthritis (OA). Circular RNA (circRNA) has been identified as important epigenetic factor in numerous diseases. However, the biological roles of inflammation-related circRNAs in regulating OA pathogenesis remain elusive. Here, we revealed circRNA expression profiles in human primary chondrocytes with interleukin-1β (IL-1β) stimulation by circRNA sequencing. We iden ...[more]

PMID: 35945200

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