Dataset Information

Retinal proteomic analysis in a mouse model of endotoxin-induced uveitis using a data-independent acquisition-based mass spectrometry

ABSTRACT: Endotoxin-induced uveitis (EIU) in rodents is a good animal model to study uveitis and associated acute retinal inflammation. To understand the pathogenic mechanism of uveitis and screen the potential targets for treatment, we analyzed the retinal proteomic profiles of EIU and normal C57BL/6J mice using a data-independent acquisition-based mass spectrometry (SWATH-MS).

INSTRUMENT(S): TripleTOF 6600

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Retina

DISEASE(S): Uveitis

SUBMITTER: Daqian LU

LAB HEAD: Dr. LIN Bin

PROVIDER: PXD033532 | Pride | 2022-08-12

REPOSITORIES: Pride

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Retinal Proteomic Analysis in a Mouse Model of Endotoxin-Induced Uveitis Using Data-Independent Acquisition-Based Mass Spectrometry.

Zhang Jing J Wu Jiangmei J Lu Daqian D To Chi-Ho CH Lam Thomas Chuen TC Lin Bin B

International journal of molecular sciences 20220609 12

Uveitis is a group of sight-threatening ocular inflammatory diseases, potentially leading to permanent vision loss in patients. However, it remains largely unknown how uveitis causes retinal malfunction and vision loss. Endotoxin-induced uveitis (EIU) in rodents is a good animal model to study uveitis and associated acute retinal inflammation. To understand the pathogenic mechanism of uveitis and screen potential targets for treatment, we analyzed the retinal proteomic profile of the EIU mouse m ...[more]

PMID: 35742911

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