Dataset Information

Quantitative proteomics of nutrient starved wildtype (WT) and MTM1 knock out (KO) HeLa cells.

ABSTRACT: Quantitative whole cell proteomics that compare fed or starved wildtype (WT) and MTM1 KO HeLa cells.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hela Cell

SUBMITTER: Wonyul Jang

LAB HEAD: Volker Haucke

PROVIDER: PXD033850 | Pride | 2022-12-22

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	L1_20210929_MN_80_VH_1stPlex_fr1.raw	Raw
	L1_20210929_MN_80_VH_1stPlex_fr10.raw	Raw
	L1_20210929_MN_80_VH_1stPlex_fr11.raw	Raw
	L1_20210929_MN_80_VH_1stPlex_fr12.raw	Raw
	L1_20210929_MN_80_VH_1stPlex_fr2.raw	Raw

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Publications

Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function.

Jang Wonyul W Puchkov Dmytro D Samsó Paula P Liang YongTian Y Nadler-Holly Michal M Sigrist Stephan J SJ Kintscher Ulrich U Liu Fan F Mamchaoui Kamel K Mouly Vincent V Haucke Volker V

Science (New York, N.Y.) 20221216 6625

Cells respond to fluctuating nutrient supply by adaptive changes in organelle dynamics and in metabolism. How such changes are orchestrated on a cell-wide scale is unknown. We show that endosomal signaling lipid turnover by MTM1, a phosphatidylinositol 3-phosphate [PI(3)P] 3-phosphatase mutated in X-linked centronuclear myopathy in humans, controls mitochondrial morphology and function by reshaping the endoplasmic reticulum (ER). Starvation-induced endosomal recruitment of MTM1 impairs PI(3)P-de ...[more]

PMID: 36520888

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