Dataset Information

Cirl Interactome in Drososphila

ABSTRACT: Identification of interaction parteners of latrophilin-type aGPCR Cirl/ADGRL in Drosophila pupea.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

SUBMITTER: Mohamed Ali Jarboui

LAB HEAD: Mohamed Ali Jarboui

PROVIDER: PXD033873 | Pride | 2023-01-16

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	FKL3348-S14-A-Cirl7TM-RFP-LAT862_1.raw	Raw
	FKL3348-S15-A-Cirl7TM-RFP-LAT862_2.raw	Raw
	FKL3348-S16-A-Cirl7TM-RFP-LAT862_3.raw	Raw
	FKL3348-S26-A-nSyb_RFP-TAG192_1.raw	Raw
	FKL3348-S27-A-nSyb_RFP-TAG192_2.raw	Raw

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Publications

Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation.

Scholz Nicole N Dahse Anne-Kristin AK Kemkemer Marguerite M Bormann Anne A Auger Genevieve M GM Vieira Contreras Fernando F Ernst Lucia F LF Staake Hauke H Körner Marek B MB Buhlan Max M Meyer-Mölck Amelie A Chung Yin Kwan YK Blanco-Redondo Beatriz B Klose Franziska F Jarboui Mohamed Ali MA Ljaschenko Dmitrij D Bigl Marina M Langenhan Tobias T

Nature 20230308 7954

Adhesion G-protein-coupled receptors (aGPCRs) bear notable similarity to Notch proteins1, a class of surface receptors poised for mechano-proteolytic activation2-4, including an evolutionarily conserved mechanism of cleavage5-8. However, so far there is no unifying explanation for why aGPCRs are autoproteolytically processed. Here we introduce a genetically encoded sensor system to detect the dissociation events of aGPCR heterodimers into their constituent N-term ...[more]

PMID: 36890234

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