Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Cell, Blood
DISEASE(S): Disease Free
SUBMITTER: David Anderson
LAB HEAD: Dean Darrel Metcalfe
PROVIDER: PXD033889 | Pride | 2023-03-10
REPOSITORIES: Pride
Items per page: 1 - 5 of 70 |
Journal of extracellular vesicles 20220901 10
Activating mutations in the receptor KIT promote the dysregulated proliferation of human mast cells (huMCs). The resulting neoplastic huMCs secrete extracellular vesicles (EVs) that can transfer oncogenic KIT among other cargo into recipient cells. Despite potential contributions to diseases, KIT-containing EVs have not been thoroughly investigated. Here, we isolated and characterized KIT-EV subpopulations released by neoplastic huMCs using an immunocapture approach that selectively isolates EVs ...[more]