Proteomics

Dataset Information

0

Protein interaction partners of long non-coding RNA NUDT6 in human aortic smooth muscle cells

ABSTRACT: The long non-coding RNA NUDT6 was found to be deregulated in abdominal aortic aneurysm (AAA) with higher expression in diseased human tissue specimens versus control aortic tissue. Apart from the already well-studied DNA: RNA interaction as a natural antisense transcript to Fibroblast Growth Factor 2 (FGF2), we were interested in identifying protein interaction partners to unravel further involvement in the pathogenesis and progression of abdominal aortic aneurysm. Therefore, we performed a RNA pulldown experiment using biotinylated NUDT6 and control RNA in human aortic smooth muscle cell lysate to identify further interaction partners.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Ilka Wittig  

LAB HEAD: Lars Mägdefessel

PROVIDER: PXD033922 | Pride | 2024-01-26

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
Data_analysis.xlsx Xlsx
P21_079_HannaWinter_Ctrl_01_B.raw Raw
P21_079_HannaWinter_Ctrl_01_C.raw Raw
P21_079_HannaWinter_Ctrl_01_D.raw Raw
P21_079_HannaWinter_Ctrl_01_E.raw Raw
Items per page:
1 - 5 of 51
altmetric image

Publications

Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression.

Winter Hanna H   Winski Greg G   Busch Albert A   Chernogubova Ekaterina E   Fasolo Francesca F   Wu Zhiyuan Z   Bäcklund Alexandra A   Khomtchouk Bohdan B BB   Van Booven Derek J DJ   Sachs Nadja N   Eckstein Hans-Henning HH   Wittig Ilka I   Boon Reinier A RA   Jin Hong H   Maegdefessel Lars L  

Molecular therapy : the journal of the American Society of Gene Therapy 20230505 6

Long non-coding RNAs (lncRNAs) orchestrate various biological processes and regulate the development of cardiovascular diseases. Their potential therapeutic benefit to tackle disease progression has recently been extensively explored. Our study investigates the role of lncRNA Nudix Hydrolase 6 (NUDT6) and its antisense target fibroblast growth factor 2 (FGF2) in two vascular pathologies: abdominal aortic aneurysms (AAA) and carotid artery disease. Using tissue samples from both diseases, we dete  ...[more]

Similar Datasets

Proteomics,Multiomics Thymosin 4 protects against aortic aneurysm via endocytic regulation of growth factor signalling
2021-05-21 | PXD024162 | Pride
Genomics
| PRJNA766518 | ENA
Transcriptomics RNA-sequencing of abdominal aortic aneurysm (AAA) and control abdominal aorta tissues
2023-12-07 | GSE183464 | GEO
Transcriptomics Gene expression changes in human thoracic and abdominal aortic aneurysm tissue
2024-10-09 | GSE202267 | GEO
Transcriptomics Early pathological characterization of murine dissecting abdominal aortic aneurysms
2018-12-15 | GSE123874 | GEO
Transcriptomics RNA-sequence analysis of mouse AAA samples obtained from ApoE-/- and ApoE-/-Nur77-/- mice induced by Ang II
2021-05-21 | GSE174768 | GEO
Transcriptomics RNA-sequence analysis of mouse AAA samples obtained from wild type mice and PSGL-1-/- mice induced by DOCA plus salt or not
2020-12-31 | GSE153425 | GEO
Genomics
| PRJNA1128157 | ENA
Transcriptomics Single cell RNAseq analysis of mouse AAA sample
2020-08-04 | GSE141732 | GEO
Transcriptomics Single cell RNAseq analysis of mouse AAA samples
2018-11-01 | GSE118237 | GEO