Dataset Information

Src Family Kinases as potential therapeutic targets for chemotherapy-resistant triple negative breast cancer

ABSTRACT: Here we quantified tyrosine phosphorylation (pTyr) mediated signaling networks in chemotherapy sensitive (CS) and resistant (CR) TNBC patient derived xenografts (PDX) to gain novel therapeutic insights. We identified Src Family Kinases (SFKs) as potential therapeutic targets in CR TNBC PDXs. Additionally, we performed pTyr analysis on tumor specimens derived from TNBC patients and observed lower prevalence of SFK driven tumors.

INSTRUMENT(S): Q Exactive HF, LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Primary Cell

DISEASE(S): Breast Cancer

SUBMITTER: Ishwar Kohale

LAB HEAD: Forest M. White

PROVIDER: PXD034154 | Pride | 2022-10-13

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	IK_20170810_BEAUTY_Run1_TMT10plex_pY_IMAC2.msf	Msf
	IK_20170810_BEAUTY_Run1_TMT10plex_pY_IMAC2.raw	Raw
	IK_20170816_BEAUTY_Run2_TMT10plex_pY_IMAC4.msf	Msf
	IK_20170816_BEAUTY_Run2_TMT10plex_pY_IMAC4.raw	Raw
	IK_20170816_BEAUTY_TMT10plex_Run2_pY_Sup.RAW	Raw

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Publications

Identification of Src Family Kinases as Potential Therapeutic Targets for Chemotherapy-Resistant Triple Negative Breast Cancer.

Kohale Ishwar N IN Yu Jia J Zhuang Yongxian Y Fan Xiaoyang X Reddy Raven J RJ Sinnwell Jason J Kalari Krishna R KR Boughey Judy C JC Carter Jodi M JM Goetz Matthew P MP Wang Liewei L White Forest M FM

Cancers 20220830 17

Neoadjuvant chemotherapy (NAC) remains the cornerstone of the treatment for triple negative breast cancer (TNBC), with the goal of complete eradication of disease. However, for patients with residual disease after NAC, recurrence and mortality rates are high and the identification of novel therapeutic targets is urgently needed. We quantified tyrosine phosphorylation (pTyr)-mediated signaling networks in chemotherapy sensitive (CS) and resistant (CR) TNBC patient-derived xenografts (PDX), to gai ...[more]

PMID: 36077757

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