Proteomics

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Structure of Cancer Antigen Mesothelin and Its Complex with Therapeutic Antibodies

ABSTRACT: Mesothelin is a differentiation antigen expressed at high levels on the surface of many cancers; its interaction with cancer antigen CA-125 can lead to metastasis. Mesothelin has been the subject of intensive investigations as a potential cancer antigen for immunotherapy. Structures of a fragment of mesothelin, full-length mesothelin alone and in complex with the Fab fragment of the therapeutic antibody MORAb-009, as well as a complex of its C-terminal fragment containing the majority of the identified shedding sites, or the shedding-resistant fragment, with monoclonal antibody 15B6 were obtained. The glycosylation profile of mesothelin purified from A431/H9 cells and patient ascites were obtained by glycoproteomics

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma, Epithelial Cell, Cell Culture

DISEASE(S): Malignant Neoplasm Of Ovary

SUBMITTER: Asif Shajahan  

LAB HEAD: Parastoo Azadi

PROVIDER: PXD034397 | Pride | 2023-05-10

REPOSITORIES: Pride

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Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies.

Zhan Jingyu J   Lin Dong D   Watson Nathan N   Esser Lothar L   Tang Wai Kwan WK   Zhang Alex A   Liu Xiufen X   Hassan Raffit R   Gleinich Anne A   Shajahan Asif A   Azadi Parastoo P   Pastan Ira I   Xia Di D  

Cancer research communications 20230201 2

The tumor-associated antigen mesothelin is expressed at high levels on the cell surface of many human cancers, while its expression in normal tissues is limited. The binding of mesothelin to the tumor-associated cancer antigen 125 (CA-125) can lead to heterotypic cell adhesion and tumor metastasis within the pleural and peritoneal cavities. Immunotherapeutic strategies targeting mesothelin are being intensively investigated. Here, we report the crystal structures of mesothelin that reveal a comp  ...[more]

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