Proteomics

Dataset Information

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Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult – SWATH proteomics


ABSTRACT: The well-known difference in sensitivity of mice and rats to acetaminophen (APAP) liver injury has been related to differences in the fraction that is bioactivated to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI). Physiologically-based pharmacokinetic modelling was used to identify doses of APAP (300 and 1000 mg/kg in mice and rats, respectively) yielding similar hepatic burdens of NAPQI, to enable the comparison of temporal liver tissue responses under conditions of equivalent chemical insult.

INSTRUMENT(S): TripleTOF 6600

ORGANISM(S): Rattus Norvegicus (rat) Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Giusy Russomanno  

LAB HEAD: Ian Copple

PROVIDER: PXD034438 | Pride | 2023-08-31

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
GR_B1_M33_SWATH_040820.wiff Wiff
GR_B1_M33_SWATH_040820.wiff.dia.quant Wiff
GR_B1_M33_SWATH_040820.wiff.scan Wiff
GR_B1_M43_SWATH_040820.wiff Wiff
GR_B1_M43_SWATH_040820.wiff.dia.quant Wiff
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