Proteomics

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Prtg+ve Rhombic Lip Ventricular Zone Stem Cells Initiate and Maintain Group 3 Medulloblastoma

ABSTRACT: PRTG+ve cells show high self renewability in Group 3 medulloblastoma tumors. To access the proteins differentially expressed in this subset of cells, we sorted PRTG+ve and PRTG-ve cells by surface staining with Anti-PRTG antibody from Gr3 medulloblastoma xenografts.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Brain Cancer

SUBMITTER: Abhirami Visvanathan  

LAB HEAD: Dr. Michael D. Taylor

PROVIDER: PXD034890 | Pride | 2024-07-31

REPOSITORIES: Pride

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Dataset's files

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Action DRS
051_PRTG_Neg.raw Raw
051_PRTG_Pos.raw Raw
20210601_LFQ_Results.msf Msf
20210611_LFQ_Results.msf Msf
211_PRTG_Neg.raw Raw
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Publications

Early rhombic lip Protogenin<sup>+ve</sup> stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma.

Visvanathan Abhirami A   Saulnier Olivier O   Chen Chuan C   Haldipur Parthiv P   Orisme Wilda W   Delaidelli Alberto A   Shin Seungmin S   Millman Jake J   Bryant Andrew A   Abeysundara Namal N   Wu Xujia X   Hendrikse Liam D LD   Patil Vikas V   Bashardanesh Zahedeh Z   Golser Joseph J   Livingston Bryn G BG   Nakashima Takuma T   Funakoshi Yusuke Y   Ong Winnie W   Rasnitsyn Alexandra A   Aldinger Kimberly A KA   Richman Cory M CM   Van Ommeren Randy R   Lee John J Y JJY   Ly Michelle M   Vladoiu Maria C MC   Kharas Kaitlin K   Balin Polina P   Erickson Anders W AW   Fong Vernon V   Zhang Jiao J   Suárez Raúl A RA   Wang Hao H   Huang Ning N   Pallota Jonelle G JG   Douglas Tajana T   Haapasalo Joonas J   Razavi Ferechte F   Silvestri Evelina E   Sirbu Olga O   Worme Samantha S   Kameda-Smith Michelle M MM   Wu Xiaochong X   Daniels Craig C   MichaelRaj Antony K AK   Bhaduri Aparna A   Schramek Daniel D   Suzuki Hiromichi H   Garzia Livia L   Ahmed Nabil N   Kleinman Claudia L CL   Stein Lincoln D LD   Dirks Peter P   Dunham Christopher C   Jabado Nada N   Rich Jeremy N JN   Li Wei W   Sorensen Poul H PH   Wechsler-Reya Robert J RJ   Weiss William A WA   Millen Kathleen J KJ   Ellison David W DW   Dimitrov Dimiter S DS   Taylor Michael D MD  

Cell 20240705 17

We identify a population of Protogenin-positive (PRTG<sup>+ve</sup>) MYC<sup>high</sup> NESTIN<sup>low</sup> stem cells in the four-week-old human embryonic hindbrain that subsequently localizes to the ventricular zone of the rhombic lip (RL<sup>VZ</sup>). Oncogenic transformation of early Prtg<sup>+ve</sup> rhombic lip stem cells initiates group 3 medulloblastoma (Gr3-MB)-like tumors. PRTG<sup>+ve</sup> stem cells grow adjacent to a human-specific interposed vascular plexus in the RL<sup>VZ</su  ...[more]

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