Proteomics

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DNA sequence and chromatin modifiers cooperate to confer epigenetic bistability at imprinting control regions

ABSTRACT: DNA methylation is essential for embryonic development and implicated in the regulation of genomic imprinting. Genomic imprinting is established in the germline through parent-specific methylation of distinct cis-regulatory DNA sequences, called imprinting control regions (ICRs). Which factors bind to the opposing chromatin states at ICRs within the same nuclear environment was not systematically addressed. By using a proximity labelling approach with the methylation sensitive transcription factor ZFP57, we identified ATF7IP and other major components of the epigenetic maintenance machinery at ICRs.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture, Embryonic Stem Cell

SUBMITTER: Tuncay Baubec  

LAB HEAD: Tuncay Baubec

PROVIDER: PXD034918 | Pride | 2023-03-10

REPOSITORIES: Pride

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Dataset's files

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Action DRS
20190923_003_S204316_SB009_KRAB_TurboID_12h_1_KRAB_TurboID.raw Raw
20190923_004_S204302_SB001_13x-TurboID_12h_1_TurboID.raw Raw
20190923_005_S204306_SB005_ZFP57FL_TurboID_12h_1_ZFP57FL_TurboID.raw Raw
20190923_007_S204319_SB012_KRAB_TurboID_12h_4_KRAB_TurboID.raw Raw
20190923_008_S204308_SB007_ZFP57FL_TurboID_12h_3_ZFP57FL_TurboID.raw Raw
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Publications

Genomic imprinting is regulated by parental-specific DNA methylation of imprinting control regions (ICRs). Despite an identical DNA sequence, ICRs can exist in two distinct epigenetic states that are memorized throughout unlimited cell divisions and reset during germline formation. Here, we systematically study the genetic and epigenetic determinants of this epigenetic bistability. By iterative integration of ICRs and related DNA sequences to an ectopic location in the mouse genome, we first ide  ...[more]

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