Proteomics

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Investigating proteome remodeling as a function of mammalian cell size

ABSTRACT: Investigating proteome remodeling as a function of mammalian cell size Experiment design: Condition1: RPE1 cells treated with palbociclib (2days) Condition 2: RPE1 cells treated with palbociclib (6days) Condition 3: RPE1 cells treated with palbociclib (6days) +Torin1 Condition 4: RPE1 cells treated with palbociclib (6days) contact inhibited

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Federico Uliana  

LAB HEAD: Federico Uliana

PROVIDER: PXD034934 | Pride | 2024-01-26

REPOSITORIES: Pride

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Publications

Genome homeostasis defects drive enlarged cells into senescence.

Manohar Sandhya S   Estrada Marianna E ME   Uliana Federico F   Vuina Karla K   Alvarez Patricia Moyano PM   de Bruin Robertus A M RAM   Neurohr Gabriel E GE  

Molecular cell 20231116 22

Cellular senescence refers to an irreversible state of cell-cycle arrest and plays important roles in aging and cancer biology. Because senescence is associated with increased cell size, we used reversible cell-cycle arrests combined with growth rate modulation to study how excessive growth affects proliferation. We find that enlarged cells upregulate p21, which limits cell-cycle progression. Cells that re-enter the cell cycle encounter replication stress that is well tolerated in physiologicall  ...[more]

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