A proteomic platform unveils PGK1 and 2 as potential target for Tatridin A
Ontology highlight
ABSTRACT: A multi-disciplinary strategy has been developed and applied for identifying Tatridin A target(s) to fully address its mechanism of action, based on drug affinity response target stability and targeted limited proteolysis. Both approaches point to the identification of PGK 1 and 2 (phospoglicerate kinase 1 and 2) as major Tatridin A targets in THP-1 cell lysates, giving also detailed insights into the ligand/proteins interaction sites.
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Monocyte, Cell Culture
SUBMITTER:
Giusy Ferraro
LAB HEAD: Maria Chiara Monti
PROVIDER: PXD034940 | Pride | 2023-07-31
REPOSITORIES: Pride
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