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A proteomic platform unveils PGK1 and 2 as potential target for Tatridin A

ABSTRACT: A multi-disciplinary strategy has been developed and applied for identifying Tatridin A target(s) to fully address its mechanism of action, based on drug affinity response target stability and targeted limited proteolysis. Both approaches point to the identification of PGK 1 and 2 (phospoglicerate kinase 1 and 2) as major Tatridin A targets in THP-1 cell lysates, giving also detailed insights into the ligand/proteins interaction sites.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Monocyte, Cell Culture

SUBMITTER: Giusy Ferraro

LAB HEAD: Maria Chiara Monti

PROVIDER: PXD034940 | Pride | 2023-07-31

REPOSITORIES: pride

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			Action	DRS
	20211203_TATA_DARTS1-2_b1.msf	Msf
	20211203_TATA_DARTS1-2_b2.msf	Msf
	20211203_TATA_DARTS1-2_b3.msf	Msf
	20211203_TATA_DARTS1-2_b4.msf	Msf
	20211203_TATA_DARTS1-2_b5.msf	Msf

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