Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain Cell Line, Pericyte Cell Differentiation, Fibroblast
DISEASE(S): Type 2 Diabetes Mellitus
SUBMITTER: Charlotte Welinder
LAB HEAD: Malin Wennström
PROVIDER: PXD035048 | Pride | 2023-03-11
REPOSITORIES: Pride
Action | DRS | |||
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MW_2106_0113_U1.mzML | Mzml | |||
MW_2106_0113_U1.raw | Raw | |||
MW_2106_0115_U2.mzML | Mzml | |||
MW_2106_0115_U2.raw | Raw | |||
MW_2106_0117_U3.mzML | Mzml |
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Molecular brain 20230215 1
The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for the pancreas, but also for the brain. In the latter, IAPP is often found in vessels, where it is highly toxic for pericytes, mural cells that have contractile properties and regulate capillary blood flow. In the current study, we use a microvasculature model, where human brain vascular peric ...[more]