Proteomic profiling of extracellular vesicles from cancer-associated fibroblast-induced myeloid-derived suppressor cells and related cell types
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ABSTRACT: Cancer-associated fibroblast (CAF) promote immune suppression in the tumor microenvironment by polarizing monocytes to myeloid-derived suppressor cells (MDSC) that potently suppress T-cell function. Using a patient-derived coculture system, we found that extracellular vesicles (EV) released by CAF-induced MDSC directly suppress T-cell proliferation. In this study, we profiled the protein cargo of the EVs isolated from CAF-MDSC and compared to related cell types.
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Myeloid Suppressor Cell
DISEASE(S): Lung Squamous Cell Carcinoma
SUBMITTER: Carlo Ramil
LAB HEAD: An Chi
PROVIDER: PXD035248 | Pride | 2024-01-03
REPOSITORIES: Pride
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