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Characterization of the interactome profiling of Mycoplasma DnaK in cancer cell reveals interference with key cellular pathways

ABSTRACT: Chaperone proteins are redundant in nature and, to achieve their function, they bind a large repertoire of client proteins. DnaK is a bacterial chaperone protein that recognizes misfolded and aggregated proteins and drives their folding and intracellular trafficking. Some Mycoplasmas are associated with cancers, and we demonstrated that infection with a strain of Mycoplasma fermentans isolated in our lab promoted lymphoma in a mouse model. Its DnaK is expressed intracellularly in infected cells, it interacts with key proteins to hamper essential pathways related to DNA repair and p53 functions and uninfected cells can take-up extracellular DnaK.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Prostate Adenocarcinoma,Colon Cancer,Neuroblastoma

SUBMITTER: Nicholas Sherman

LAB HEAD: Davide Zella

PROVIDER: PXD035477 | Pride | 2022-10-12

REPOSITORIES: Pride

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			Action	DRS
	AGS.sf3	Other
	D_Zella_Paper.xlsx	Xlsx
	H446.sf3	Other
	HCT116.sf3	Other
	IP_only_Human_DB.sf3	Other

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