Proteomics

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Complexome profiling of mitochondrial protein complexes from pig heart to study the molecular consequences of hyperbaric oxygen treatment

ABSTRACT: The overall goal of the project was to confirm the presence of different energetic states of mitochondrial subpopulations depending on their subcellular localization within cardiomyocytes, i.e., subsarcolemmal (SSM) and interfibrillar mitochondria (IFM). At the same time, we aimed to elucidate possible respiratory plasticity of mitochondrial states in response to oxygen availability because of treatment with hyperbaric oxygen. The results could form the basis for a more efficient therapy of contractile dysfunction of the heart but also of other diseases if they are due to mitochondrial respiratory dysfunction caused by a lack of tissue oxygenation.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Heart

SUBMITTER: Ilka Wittig  

LAB HEAD: Marten Szibor

PROVIDER: PXD035554 | Pride | 2024-06-22

REPOSITORIES: Pride

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20131106_Pig_SSM_Ctr_Wittig_MB01.raw Raw
20131106_Pig_SSM_Ctr_Wittig_MB02.raw Raw
20131106_Pig_SSM_Ctr_Wittig_MB03.raw Raw
20131106_Pig_SSM_Ctr_Wittig_MB04.raw Raw
20131106_Pig_SSM_Ctr_Wittig_MB05.raw Raw
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Publications

Hyperbaric oxygen treatment reveals spatiotemporal OXPHOS plasticity in the porcine heart.

Heidler Juliana J   Cabrera-Orefice Alfredo A   Wittig Ilka I   Heyne Estelle E   Tomczak Jan-Niklas JN   Petersen Bjoern B   Henze Dirk D   Pohjoismäki Jaakko L O JLO   Szibor Marten M  

PNAS nexus 20240530 6

Cardiomyocytes meet their high ATP demand almost exclusively by oxidative phosphorylation (OXPHOS). Adequate oxygen supply is an essential prerequisite to keep OXPHOS operational. At least two spatially distinct mitochondrial subpopulations facilitate OXPHOS in cardiomyocytes, i.e. subsarcolemmal (SSM) and interfibrillar mitochondria (IFM). Their intracellular localization below the sarcolemma or buried deep between the sarcomeres suggests different oxygen availability. Here, we studied SSM and  ...[more]

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