Proteomics

Dataset Information

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Tear protein profile in eyes with keratoconus after one year of intrastromal corneal ring and corneal crosslinking: a pilot study


ABSTRACT: Keratoconus (KC) is a corneal ectasia characterized by structural changes, resulting in progressive thinning and biomechanical weakening that can lead to worsening visual acuity due to irregular astigmatism. Corneal collagen Crosslinking (CXL) and Intracorneal Ring Segment (ICRS) are widely used treatments in KC disease, but the alterations they cause in biomechanical mediators are still poorly understood. The aim of this study was to analyze the tear proteome profile before and after treatments to identify biomarkers altered by surgery.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Tear

DISEASE(S): Keratoconus

SUBMITTER: Mikel Azkargorta  

LAB HEAD: Felix Elortza

PROVIDER: PXD035655 | Pride | 2022-10-14

REPOSITORIES: Pride

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Publications

Tear proteome profile in eyes with keratoconus after intracorneal ring segment implantation or corneal crosslinking.

Goñi Nahia N   Martínez-Soroa Itziar I   Ibarrondo Oliver O   Azkargorta Mikel M   Elortza Felix F   Galarreta David J DJ   Acera Arantxa A  

Frontiers in medicine 20220920


<h4>Purpose</h4>Keratoconus (KC) is a corneal ectasia characterized by structural changes, resulting in progressive thinning and biomechanical weakening that can lead to worsening visual acuity due to irregular astigmatism. Corneal collagen Crosslinking (CXL) and Intracorneal Ring Segment (ICRS) are widely used treatments in KC disease, but the alterations they cause in biomechanical mediators are still poorly understood. The aim of this study was to analyze the tear proteome profile before and  ...[more]

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