Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hepatocyte
SUBMITTER: Doeun Kim
LAB HEAD: Sangkyu Lee
PROVIDER: PXD035758 | Pride | 2023-03-11
REPOSITORIES: Pride
Items per page: 1 - 5 of 60 |
International journal of molecular sciences 20221014 20
The well-known hepatotoxicity mechanism resulting from alpha-amanitin (α-AMA) exposure arises from RNA polymerase II (RNAP II) inhibition. RNAP Ⅱ inhibition occurs through the dysregulation of mRNA synthesis. However, the signaling pathways in hepatocytes that arise from α-AMA have not yet been fully elucidated. Here, we identified that the RAS/RAF/ERK signaling pathway was activated through quantitative phosphoproteomic and molecular biological analyses in Huh-7 cells. Bioinformatics analysis s ...[more]