Proteomics

Dataset Information

0

Proteomics of human naive pluripotent and trophoblastic stem cells

ABSTRACT: This project aims at identifying missing proteins in naive pluripotent and trophoblastic stem cells in the framework of the human proteome project (HPP). To date, as much as 1343 missing proteins remain to be credibly identified essentially, but not entirely, by mass spectrometry. The present results also constitute a first step towards the identification of potential biological markers for assessing stem cells and early embryo development.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stem Cell

SUBMITTER: E Com  

LAB HEAD: Charles Pineau

PROVIDER: PXD035768 | Pride | 2023-03-11

REPOSITORIES: pride

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Dataset's files

Source:
Action DRS
364_C-HPP_SCT-TamponLyse_Slot1-10_1_4751.d.zip Other
364_C-HPP_SCT-TamponLyse_Slot1-10_1_4751_DA6.0.313_1.mgf Mgf
364_C-HPP_TSC-Trypsine_Slot1-12_1_4682.d.zip Other
364_C-HPP_TSC-Trypsine_Slot1-12_1_4682_DA6.0.313_1.mgf Mgf
F001745.mzid.gz Mzid
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Publications

Naive Pluripotent and Trophoblastic Stem Cell Lines as a Model for Detecting Missing Proteins in the Context of the Chromosome-Centric Human Proteome Project.

Girard Océane O   Lavigne Régis R   Chevolleau Simon S   Onfray Constance C   Com Emmanuelle E   Schmit Pierre-Olivier PO   Chapelle Manuel M   Fréour Thomas T   Lane Lydie L   David Laurent L   Pineau Charles C  

Journal of proteome research 20221129 4

The Chromosome-centric Human Proteome Project (C-HPP) aims at identifying the proteins as gene products encoded by the human genome, characterizing their isoforms and functions. The existence of products has now been confirmed for 93.2% of the genes at the protein level. The remaining mostly correspond to proteins of low abundance or difficult to access. Over the past years, we have significantly contributed to the identification of missing proteins in the human spermatozoa. We pursue our search  ...[more]

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