Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Pancreas
SUBMITTER: Laura Brunelli
LAB HEAD: Roberta Pastorelli
PROVIDER: PXD035770 | Pride | 2023-10-24
REPOSITORIES: Pride
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Resovi Andrea A Persichitti Perla P Brunelli Laura L Minoli Lucia L Borsotti Patrizia P Garattini Giulia G Tironi Matteo M Dugnani Erica E Redegalli Miriam M De Simone Giulia G Pastorelli Roberta R Bani Maria Rosa MR Piemonti Lorenzo L Mosher Deane F DF Giavazzi Raffaella R Taraboletti Giulia G Belotti Dorina D
Journal of experimental & clinical cancer research : CR 20230809 1
<h4>Background</h4>The pancreatic microenvironment has a defensive role against cancer but it can acquire tumor-promoting properties triggered by multiple mechanisms including alterations in the equilibrium between proteases and their inhibitors. The identification of proteolytic events, targets and pathways would set the basis for the design of new therapeutic approaches.<h4>Methods and results</h4>Here we demonstrate that spheroids isolated from human and murine healthy pancreas and co-transpl ...[more]