Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Stromal Cell Of Bone Marrow
SUBMITTER: Jennifer Bethard
LAB HEAD: Jack Feehan
PROVIDER: PXD035803 | Pride | 2024-10-17
REPOSITORIES: Pride
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Feehan Jack J Tripodi Nicholas N Kondrikov Dmitry D Wijeratne Tissa T Gimble Jeffrey J Hill William W Apostolopoulos Vasso V Duque Gustavo G
The journals of gerontology. Series A, Biological sciences and medical sciences 20240901 9
The biological aging of stem cells (exhaustion) is proposed to contribute to the development of a variety of age-related conditions. Despite this, little is understood about the specific mechanisms which drive this process. In this study, we assess the transcriptomic and proteomic changes in 3 different populations of mesenchymal progenitor cells from older (50-70 years) and younger (20-40 years) individuals to uncover potential mechanisms driving stem cell exhaustion in mesenchymal tissues. To ...[more]