Proteomics

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Integrative transcriptomic and proteomic analysis show circulating osteoprogenitors to have a mixed immune and mesenchymal progenitor function in humans


ABSTRACT: Circulating osteoprogenitor (COP) are a population of cell in the peripheral circulation that possess functional and phenotypical characteristics of multipotent stromal cells (MSCs). While there is functional overlap, it is not known how COP cells are related to bone marrow (BM)-derived MSCs (BM-MSCs) and other better characterized stromal progenitor populations such as adipose-derived stromal cells (ASCs). This study compares COP cells to BM-MSCs and ASCs through detailed transcriptomic and proteomic analyses. COP cells have a distinct gene and protein expression pattern to BM-MSCs and ASCs, with a significantly stronger immune footprint, likely owing to their hematopoietic lineage. However, they also have a similar pattern of expression BM-MSCs and ASCs, in genes and proteins in progenitor cell differentiation and proliferation pathways. This study shows COP cells to be a unique but functionally similar population to BM-MSCs and ASCs, sharing their proliferation and differentiation capacity, but with a strong immune phenotype, with potential for translational regenerative medicine strategies.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stromal Cell Of Bone Marrow

SUBMITTER: Jennifer Bethard  

LAB HEAD: Jack Feehan

PROVIDER: PXD035803 | Pride | 2024-10-17

REPOSITORIES: Pride

Dataset's files

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Action DRS
03122021_Hill_Feehan_OF1.raw Raw
03122021_Hill_Feehan_OF2.raw Raw
03122021_Hill_Feehan_OF3.raw Raw
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03122021_Hill_Feehan_OM1.raw Raw
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Publications

Differential Responses to Aging Among the Transcriptome and Proteome of Mesenchymal Progenitor Populations.

Feehan Jack J   Tripodi Nicholas N   Kondrikov Dmitry D   Wijeratne Tissa T   Gimble Jeffrey J   Hill William W   Apostolopoulos Vasso V   Duque Gustavo G  

The journals of gerontology. Series A, Biological sciences and medical sciences 20240901 9


The biological aging of stem cells (exhaustion) is proposed to contribute to the development of a variety of age-related conditions. Despite this, little is understood about the specific mechanisms which drive this process. In this study, we assess the transcriptomic and proteomic changes in 3 different populations of mesenchymal progenitor cells from older (50-70 years) and younger (20-40 years) individuals to uncover potential mechanisms driving stem cell exhaustion in mesenchymal tissues. To  ...[more]

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