Proteome of Mycobacterium tuberculosis treated with 2,4-disubstituted pyridine derivatives
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ABSTRACT: Two selected compounds, 2,4-disubstituted pyridine derivatives (11 and 15), revealed significant bactericidal activity against Mycobacterium tuberculosis deposited within human macrophages as well as against biofilm-forming tubercle bacilli. The mass spectrometry-based proteomics (LC-MS/MS) of the wild-type tubercle bacilli growing in the subinhibitory concentration of 11 or 15 revealed 15 overproduced proteins not detectable in the control cells including virulence-related proteins.
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mycobacterium Tuberculosis H37rv
SUBMITTER: Przemyslaw Plocinski
LAB HEAD: Jaroslaw Dziadek
PROVIDER: PXD035807 | Pride | 2022-11-02
REPOSITORIES: Pride
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