Proteomics

Dataset Information

0

Proteome of Mycobacterium tuberculosis treated with 2,4-disubstituted pyridine derivatives


ABSTRACT: Two selected compounds, 2,4-disubstituted pyridine derivatives (11 and 15), revealed significant bactericidal activity against Mycobacterium tuberculosis deposited within human macrophages as well as against biofilm-forming tubercle bacilli. The mass spectrometry-based proteomics (LC-MS/MS) of the wild-type tubercle bacilli growing in the subinhibitory concentration of 11 or 15 revealed 15 overproduced proteins not detectable in the control cells including virulence-related proteins.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mycobacterium Tuberculosis H37rv

SUBMITTER: Przemyslaw Plocinski  

LAB HEAD: Jaroslaw Dziadek

PROVIDER: PXD035807 | Pride | 2022-11-02

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
11_1.raw Raw
11_2.raw Raw
11_3.raw Raw
15_1.raw Raw
15_2.raw Raw
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