Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Kidney
SUBMITTER: Aaron Storey
LAB HEAD: Chris Larsen
PROVIDER: PXD035853 | Pride | 2023-04-06
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
Arkana_032521.sdia | Other | |||
Arkana_032521_Sample_01.dia.elib | Other | |||
Arkana_032521_Sample_01.raw | Raw | |||
Arkana_032521_Sample_02.dia.elib | Other | |||
Arkana_032521_Sample_02.raw | Raw |
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Kidney international 20230110 3
Multiple autoantigens have been identified in membranous nephropathy (MN) by tissue-based proteomics. However, antigenic targets of disease are unknown for over 10% of patients with MN and over half of those with membranous lupus nephritis (MLN). Here, we identified multiple new targets in PLA2R-/THSD7A-/EXT-/NELL1-quadruple negative MN biopsies through mass spectrometry of immune complexes recovered from biopsy tissue of patients with MN. Patients with MN negative for these four antigens were i ...[more]