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Proteomic Profiling of Breast Cancer Patient-Derived Xenograft

ABSTRACT: Mass spectrometry profiling of orthotopically transplanted breast cancer patient-derived xenograft (PDX) tumors prior to chemotherapy treatment.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

DISEASE(S): Breast Cancer

SUBMITTER: Ramakrishnan Rajaram Srinivasan

LAB HEAD: Michael T. Lewis

PROVIDER: PXD035857 | Pride | 2022-12-06

REPOSITORIES: Pride

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	33051_2_ML_162_prof_15F5R_2ug_F1.raw	Raw
	33051_2_ML_162_prof_15F5R_2ug_F2.raw	Raw
	33051_2_ML_162_prof_15F5R_2ug_F3.raw	Raw
	33051_2_ML_162_prof_15F5R_2ug_F4.raw	Raw
	33051_2_ML_162_prof_15F5R_2ug_F5.raw	Raw

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Publications

Immunologically "cold" triple negative breast cancers engraft at a higher rate in patient derived xenografts.

Petrosyan Varduhi V Dobrolecki Lacey E LE LaPlante Emily L EL Srinivasan Ramakrishnan Rajaram RR Bailey Matthew H MH Welm Alana L AL Welm Bryan E BE Lewis Michael T MT Milosavljevic Aleksandar A

NPJ breast cancer 20220910 1

TNBC is a heterogeneous subtype of breast cancer, and only a subset of TNBC can be established as PDXs. Here, we show that there is an engraftment bias toward TNBC with low levels of immune cell infiltration. Additionally, TNBC that failed to engraft show gene expression consistent with a cancer-promoting immunological state, leading us to hypothesize that the immunological state of the tumor and possibly the state of the immune system of the host may be essential for engraftment. ...[more]

PMID: 36088362

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