Proteomics

Dataset Information

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Proteomic characterization of NHL cells in presence of CDK9 inhibitor


ABSTRACT: non-Hodgkins lymphoma cells were treated with a CDK9 inhibitor to determine which proteins and phosphorylation events are affected by CDK9 in lymphoma.

INSTRUMENT(S): Orbitrap Eclipse

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

DISEASE(S): Lymphoma

SUBMITTER: Krystine Mansfield  

LAB HEAD: Patrick Pirrotte

PROVIDER: PXD035858 | Pride | 2023-05-10

REPOSITORIES: Pride

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Publications


Diffuse large B-cell lymphoma (DLBCL) exhibits significant genetic heterogeneity which contributes to drug resistance, necessitating development of novel therapeutic approaches. Pharmacological inhibitors of cyclin-dependent kinases (CDK) demonstrated pre-clinical activity in DLBCL, however many stalled in clinical development. Here we show that AZD4573, a selective inhibitor of CDK9, restricted growth of DLBCL cells. CDK9 inhibition (CDK9i) resulted in rapid changes in the transcriptome and pro  ...[more]

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