Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Pulmonary Capillary Endothelial Cell
DISEASE(S): Chronic Obstructive Pulmonary Disease
SUBMITTER: Eugene Dillon
LAB HEAD: Paul McLoughlin
PROVIDER: PXD036260 | Pride | 2023-02-17
REPOSITORIES: Pride
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American journal of respiratory cell and molecular biology 20230501 5
Blood flow produces shear stress that homeostatically regulates the phenotype of pulmonary endothelial cells, exerting antiinflammatory and antithrombotic actions and maintaining normal barrier function. Hypoxia due to diseases, such as chronic obstructive pulmonary disease (COPD), causes vasoconstriction, increased vascular resistance, and pulmonary hypertension. Hypoxia-induced changes in endothelial function play a central role in the development of pulmonary hypertension. However, the intera ...[more]