Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Melanocyte, Cell Culture
DISEASE(S): Melanoma
SUBMITTER: Kieran Wynne
LAB HEAD: Walter Kolch
PROVIDER: PXD036261 | Pride | 2023-10-24
REPOSITORIES: pride
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Oxidation__M_Sites.txt | Txt | |||
checksum.txt | Txt | |||
evidence.txt | Txt | |||
liu_B1703_IgG-1.index | Other | |||
liu_B1703_IgG-1.raw | Raw |
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International journal of molecular sciences 20230723 14
Kinase Suppressor of RAS 1 (KSR1) is a scaffolding protein for the RAS-RAF-MEK-ERK pathway, which is one of the most frequently altered pathways in human cancers. Previous results have shown that KSR1 has a critical role in mutant RAS-mediated transformation. Here, we examined the role of KSR1 in mutant BRAF transformation. We used CRISPR/Cas9 to knock out KSR1 in a BRAFV600E-transformed melanoma cell line. KSR1 loss produced a complex phenotype characterised by impaired proliferation, cell cycl ...[more]