Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell Of Large Intestine, Colon
DISEASE(S): Colorectal Cancer,Stage Iv Colorectal Cancer
SUBMITTER: Jelmer Dijkstra
LAB HEAD: Michiel Vermeulen
PROVIDER: PXD036441 | Pride | 2022-12-11
REPOSITORIES: Pride
Items per page: 1 - 5 of 44 |
Journal of proteome research 20221130 1
The development of metastasis severely reduces the life expectancy of patients with colorectal cancer (CRC). Although loss of SMAD4 is a key event in CRC progression, the resulting changes in biological processes in advanced disease and metastasis are not fully understood. Here, we applied a multiomics approach to a CRC organoid model that faithfully reflects the metastasis-supporting effects of SMAD4 inactivation. We show that loss of SMAD4 results in decreased differentiation and activation of ...[more]