Proteomics

Dataset Information

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Glycosylation Patterns on Collagen α1(I) and Collagen α2(I) resemble a lock and key arrangement


ABSTRACT: Col1 from the skins of 4 animals (cow, deer, goat and sheep) were purified, then used mass spectrometry and proteomic techniques to identify lysines that were oxidised, galactosylated, glucosylgalactosylated, or glycated in its ma-ture sequence. We found 18 out of the 38 lysines in collagen type 1α1, (Col1A1) and 7 of the 30 lysines in collagen type 1α2 (Col1A2) were glycosylated. Six of these modifications had not been reported before, and included a lysine involved in cross linking collagen molecules. Mapping the positions of these modifications on the ColA1 and Col1A2 sequences showed they were complimentary and resembled a lock and key arrangement.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Bos Taurus (bovine) Capra Hircus X Ovis Aries

TISSUE(S): Skin

SUBMITTER: Trevor Loo  

LAB HEAD: Gill Norris

PROVIDER: PXD036507 | Pride | 2023-05-24

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20190311_Tryptic_ACN1_Researched.msf Msf
20190311_Tryptic_ACN1_Researched.msfView Msf
20190311_Tryptic_ACN1_Researched.pdResult Other
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