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Human complement factor 3 LC-MS/MS

ABSTRACT: Purification of native complement factor 3 from human serum and proteolytic generation of activation fragments

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Martin Hubalek

LAB HEAD: Martin Hubálek

PROVIDER: PXD036611 | Pride | 2023-05-10

REPOSITORIES: Pride

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			Action	DRS
	190801_SZ1.mzML	Mzml
	190801_SZ1.mzid.gz	Mzid
	190801_SZ1.raw	Raw
	190801_SZ2.mzML	Mzml
	190801_SZ2.mzid.gz	Mzid

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1 - 5 of 16

Publications

Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction.

Sülzen Hagen H Began Jakub J Dhillon Arun A Kereïche Sami S Pompach Petr P Votrubova Jitka J Zahedifard Farnaz F Šubrtova Adriana A Šafner Marie M Hubalek Martin M Thompson Maaike M Zoltner Martin M Zoll Sebastian S

Nature communications 20230427 1

African Trypanosomes have developed elaborate mechanisms to escape the adaptive immune response, but little is known about complement evasion particularly at the early stage of infection. Here we show that ISG65 of the human-infective parasite Trypanosoma brucei gambiense is a receptor for human complement factor C3 and its activation fragments and that it takes over a role in selective inhibition of the alternative pathway C5 convertase and thus abrogation of the terminal pathway. No deposition ...[more]

PMID: 37105991

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