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Flycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 2/6

ABSTRACT: During discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide barcodes, called flycodes, allows for the simultaneous preclinical assessment of dozens of antibodies from single cassette-dosed mice. Datasets: 1. comparison of flycodes vs. unique endogenous tryptic peptides for antibody identification 2. antibody PK, cassette dose A (high dose) 3. antibody PK, cassette dose B (low dose) 4. antibody tumor/organ biodistribution 5. Dar-SB thermostability 6. Dar-SB PK

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Justin Walter

LAB HEAD: Markus Seeger

PROVIDER: PXD036734 | Pride | 2025-02-26

REPOSITORIES: pride

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			Action	DRS
	20211020_002_S322596_20211020_input_B_SHL4-PK_A.raw	Raw
	20211020_014a_S322604_20211020_m1-t8_A.raw	Raw
	20211020_015_S322605_20211020_m4-t1_A.raw	Raw
	20211020_016_S322606_20211020_m4-t2_A.raw	Raw
	20211020_017_S322607_20211020_m4-t3_A.raw	Raw

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