Dataset Information
: Proximity proteomics identifies endothelial cell septins and PAK2 as decisive regulators of actomyosin mediated expulsion of von Willebrand factor.
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Vein Endothelial Cell, Umbilical Vein
SUBMITTER: 
Vinothini Rajeeve
LAB HEAD: Professor Pedro R Cutillas
PROVIDER: PXD036983 | Pride | 2023-01-11
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| F005361.mzid.gz | Mzid | |||
| F005362.mzid.gz | Mzid | |||
| F005363.mzid.gz | Mzid | |||
| F005364.mzid.gz | Mzid | |||
| F005365.mzid.gz | Mzid |
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Publications
Proximity proteomics identifies septins and PAK2 as decisive regulators of actomyosin-mediated expulsion of von Willebrand factor.
Blood 20230201 8
In response to tissue injury, within seconds the ultra-large glycoprotein von Willebrand factor (VWF) is released from endothelial storage organelles (Weibel-Palade bodies) into the lumen of the blood vasculature, where it leads to the recruitment of platelets. The marked size of VWF multimers represents an unprecedented burden on the secretory machinery of endothelial cells (ECs). ECs have evolved mechanisms to overcome this, most notably an actomyosin ring that forms, contracts, and squeezes o ...[more]
