Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Bos Taurus (bovine)
TISSUE(S): Epithelial Cell, Retinal Pigment Epithelium Cell
SUBMITTER: zhemin zhang
LAB HEAD: Edward W. Yu
PROVIDER: PXD037186 | Pride | 2023-01-02
REPOSITORIES: Pride
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Lum_21nov3011.raw | Raw | |||
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Morgan Christopher E CE Zhang Zhemin Z Miyagi Masaru M Golczak Marcin M Yu Edward W EW
Cell reports 20221201 13
The use of an integrated systems biology approach to investigate tissues and organs has been thought to be impracticable in the field of structural biology, where the techniques mainly focus on determining the structure of a particular biomacromolecule of interest. Here, we report the use of cryoelectron microscopy (cryo-EM) to define the composition of a raw bovine retinal pigment epithelium (RPE) lysate. From this sample, we simultaneously identify and solve cryo-EM structures of seven differe ...[more]