Dataset Information

LFQ proteomics analysis of M. smegmatis treated with CymA and ecumicin (Part 2).

ABSTRACT: To assess the impact of the bactericidal compounds CymA and ecumicin on the mycobacterial proteome and to monitor proteome remodeling by the AAA+ ClpC1 protease machinery, we performed a LFQ proteomics analysis treating the cells at bactericidal compound concentration. We identified new players of the mycobacterial ClpC1 stress response (ClpC2 and ClpC3), as novel bacterial antibiotic resistance mechanism.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Mycobacterium Smegmatis (strain Atcc 700084 / Mc(2)155)

SUBMITTER: David Hoi

LAB HEAD: Markus Hartl

PROVIDER: PXD037234 | Pride | 2023-06-07

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	20211115_E3_RSLC6_Hoi_Clausen_IMP_C2KO_DMSO_2h_rep1.raw	Raw
	20211115_E3_RSLC6_Hoi_Clausen_IMP_C2KO_DMSO_2h_rep1_-45.mzxml	Mzxml
	20211115_E3_RSLC6_Hoi_Clausen_IMP_C2KO_DMSO_2h_rep1_-60.mzxml	Mzxml
	20211115_E3_RSLC6_Hoi_Clausen_IMP_C2KO_DMSO_2h_rep1_-75.mzxml	Mzxml
	20211115_E3_RSLC6_Hoi_Clausen_IMP_C2KO_DMSO_2h_rep2.raw	Raw

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Dataset Information

LFQ proteomics analysis of M. smegmatis treated with CymA and ecumicin (Part 2).

Dataset's files

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