Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Lung, Epithelial Cell
SUBMITTER: Christian Münch
LAB HEAD: Christian Münch
PROVIDER: PXD037265 | Pride | 2023-05-10
REPOSITORIES: Pride
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Molecular & cellular proteomics : MCP 20230330 5
The ancestral SARS-CoV-2 strain that initiated the Covid-19 pandemic at the end of 2019 has rapidly mutated into multiple variants of concern with variable pathogenicity and increasing immune escape strategies. However, differences in host cellular antiviral responses upon infection with SARS-CoV-2 variants remain elusive. Leveraging whole-cell proteomics, we determined host signaling pathways that are differentially modulated upon infection with the clinical isolates of the ancestral SARS-CoV-2 ...[more]