Proteomics

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Attenuated inflammatory profile following single and repeated handgrip exercise and remote ischemic preconditioning in patients with cerebral small vessel disease


ABSTRACT: Similar to remote ischemic preconditioning bouts of exercise may possess immediate protective effects against ischemia-reperfusion injury. However, underlying mechanisms are largely unknown. This study compared the impact of single and repeated handgrip exercise versus remote ischemic preconditioning on inflammatory biomarkers in patients with cerebral small vessel disease (cSVD). In this crossover study, 14 patients with cSVD were included. All participants performed 4-days of handgrip exercise (4x5-minutes at 30% of maximal handgrip strength) and remote ischemic preconditioning (rIPC; 4x5-minutes cuff occlusion around the upper arm) twice daily. Patients were randomized to start with either handgrip exercise or rIPC and the two interventions were separated by >9 days. Venous blood was drawn before and after one intervention, and after 4-days of repeated exposure. We performed a targeted proteomics on inflammation markers in all blood samples.

INSTRUMENT(S): Not available

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Thijs Landman  

LAB HEAD: DHJ Thijssen

PROVIDER: PXD037267 | Pride | 2023-03-11

REPOSITORIES: Pride

Dataset's files

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Action DRS
CONDITIONED_NPX_raw.xlsx Xlsx
Protein_identification.xlsx Xlsx
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Publications

Attenuated inflammatory profile following single and repeated handgrip exercise and remote ischemic preconditioning in patients with cerebral small vessel disease.

Landman Thijs R J TRJ   Uthman Laween L   Hofmans Inge A H IAH   Schoon Yvonne Y   de Leeuw Frank-Erik FE   Thijssen Dick H J DHJ  

Frontiers in physiology 20221121


<b>Background:</b> Similar to remote ischemic preconditioning bouts of exercise may possess immediate protective effects against ischemia-reperfusion injury. However, underlying mechanisms are largely unknown. This study compared the impact of single and repeated handgrip exercise versus remote ischemic preconditioning on inflammatory biomarkers in patients with cerebral small vessel disease (cSVD). <b>Methods:</b> In this crossover study, 14 patients with cSVD were included. All participants pe  ...[more]

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