Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Pancreatic Cancer
SUBMITTER: GIYONG JANG
LAB HEAD: Charles Lee
PROVIDER: PXD037275 | Pride | 2023-03-11
REPOSITORIES: Pride
Action | DRS | |||
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homo_sapiens_panc0203_mascot.zip | Other | |||
homo_sapiens_panc0203_mzML.zip | Other |
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NPJ genomic medicine 20221027 1
Pancreatic cancer exhibits a characteristic tumor microenvironment (TME) due to enhanced fibrosis and hypoxia and is particularly resistant to conventional chemotherapy. However, the molecular mechanisms underlying TME-associated treatment resistance in pancreatic cancer are not fully understood. Here, we developed an in vitro TME mimic system comprising pancreatic cancer cells, fibroblasts and immune cells, and a stress condition, including hypoxia and gemcitabine. Cells with high viability und ...[more]